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Coagulation parameters abnormalities and their relation to clinical outcomes in hospitalized and severe COVID-19

Hend M Esmaeel1, Heba A Ahmed2, Mahmoud I Elbadry3

  • 1Department of Chest Disease and Tuberculosis, Faculty of Medicine, Sohag University, Sohag, 82524, Egypt. hendomr@gmail.com.

Scientific Reports
|August 1, 2022
PubMed

Insights

Coagulation abnormalities, including D-dimer and Anti-Thrombin III, effectively predict COVID-19 severity and poor outcomes. Monitoring these markers aids in early risk assessment and patient management.

Area of Science:

  • Hematology
  • Virology
  • Clinical Medicine

Background:

  • Growing attention on coagulation parameter abnormalities in predicting COVID-19 severity.
  • Coagulation disorders are increasingly recognized as a significant factor in COVID-19 prognosis.

Purpose of the Study:

  • To investigate the predictive role of coagulation parameters (Prothrombin concentration, aPTT, D-Dimer, ATIII, fibrinogen) in COVID-19 severity.
  • To assess the relationship between coagulation, hematological, and biochemical parameters and clinical outcomes in hospitalized and severe COVID-19 patients.

Main Methods:

  • Prospective study of 267 newly diagnosed COVID-19 patients.
  • Patients categorized into hospitalized/non-hospitalized and severe/non-severe groups.
  • Clinical evaluation, measurement of coagulation, hematological, and biochemical parameters, and outcome data collection.

Main Results:

  • Hospitalized and severe COVID-19 patients were older and presented more frequently with dyspnea.
  • Significant differences in coagulation and inflammatory markers were observed between severity groups.
  • D-dimer, AT-III, and LDH demonstrated excellent independent prediction of severity risk (D-dimer: 76% sensitivity, 93% specificity at >2.0 ng/L).
  • Patients with coagulation abnormalities had significantly worse survival rates (p=0.002).

Conclusions:

  • Coagulation parameters, particularly D-dimer and AT-III, are valuable predictors of COVID-19 severity.
  • Early assessment and monitoring of coagulation status can aid in predicting COVID-19 severity and mortality risk.

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