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Updated: Sep 2, 2025

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers
Published on: October 23, 2018
On-the-fly investigation of XUV excited large molecular ions using a high harmonic generation light source
Marius Hervé1, Alexie Boyer1, Richard Brédy2
1Univ Lyon, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière (UMR 5306 CNRS), 10 rue Ada Byron, Campus Lyon Tech La Doua, 69622, Villeurbanne Cedex, France.
Abstract:
We present experiments where extreme ultraviolet femtosecond light pulses are used to photoexcite large molecular ions at high internal energy. This is done by combining an electrospray ionization source and a mass spectrometer with a pulsed light source based on high harmonic generation. This allows one to study the interaction between high energy photons and mass selected ions in conditions that are accessible on large-scale facilities. We show that even without an ion trapping device, systems as large as a protein can be studied. We observe light induced dissociative ionization and proton migration in model systems such as reserpine, insulin and cytochrome c. These results offer new perspectives to perform time-resolved experiments with ultrashort pulses at the heart of the emerging field of attosecond chemistry.
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