Related Experiment Video

Updated: Sep 2, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

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Published on: June 14, 2016

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Coronary microvascular disease in hypertrophic and infiltrative cardiomyopathies

Andreas A Giannopoulos1, Ronny R Buechel1, Philipp A Kaufmann2

  • 1Department of Nuclear Medicine, Cardiac Imaging, University Hospital and University Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|August 1, 2022
PubMed

Insights

Pathologic cardiac hypertrophy is linked to coronary microvascular disease. Advanced imaging reveals how this dysfunction impacts hypertrophy progression, offering insights for clinical practice.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Medical Imaging

Background:

  • Pathologic cardiac hypertrophy is a common clinical finding linked to various diseases.
  • Coronary microvascular disease plays a significant role in the progression of cardiac hypertrophy.
  • Understanding this interplay is crucial for managing cardiac conditions.

Purpose of the Study:

  • To summarize current knowledge on coronary microvascular dysfunction in pathologic cardiac hypertrophy.
  • To highlight the role of non-invasive imaging in understanding these mechanisms.
  • To provide a comprehensive overview for clinicians and researchers.

Main Methods:

  • Review of current literature on cardiac hypertrophy and coronary microvascular dysfunction.
  • Focus on insights gained from non-invasive imaging techniques.
  • Inclusion of data from positron emission tomography and cardiac magnetic resonance.

Main Results:

  • Coronary microvascular dysfunction is a key factor in the pathophysiology of cardiac hypertrophy.
  • Non-invasive imaging modalities have elucidated the mechanisms linking hypertrophy and microvasculature.
  • Specific patterns of microvascular dysfunction are associated with different forms of hypertrophy.

Conclusions:

  • Coronary microvascular dysfunction is integral to the development and progression of pathologic cardiac hypertrophy.
  • Non-invasive imaging is essential for diagnosing and understanding this relationship.
  • Further research into therapeutic strategies targeting coronary microvasculature is warranted.

Keywords:
CMDCMRCoronary microvascular diseasecardiac PETcoronary flow reserveleft ventricular hypertrophy

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