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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

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Related Experiment Video

Updated: Sep 2, 2025

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

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Fighting fibrosis

Melanie Senior¹

¹, London, UK.

Nature Biotechnology

|August 1, 2022

Summary

No abstract available in PubMed .

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