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TG/HDL-C ratio predicts in-hospital mortality in patients with acute type A aortic dissection

Yan-Juan Lin1, Jian-Long Lin2, Yan-Chun Peng3

  • 1Department of Nursing, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China. fjxhyjl@163.com.

BMC Cardiovascular Disorders
|August 1, 2022
PubMed

Insights

The triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is linked to higher in-hospital mortality in patients with acute type A aortic dissection (AAAD). This lipid ratio may serve as a valuable prognostic marker for AAAD patients.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Aortic Diseases

Background:

  • Abnormalities in serum lipids and lipoproteins are associated with cardiovascular disease risk.
  • The prognostic value of lipid profiles for acute type A aortic dissection (AAAD) remains unclear.
  • This study investigates the clinical significance of preoperative blood lipids on AAAD prognosis.

Purpose of the Study:

  • To analyze the correlation between the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and in-hospital mortality in patients with AAAD.
  • To investigate the clinical significance of preoperative blood lipids and lipoproteins on the prognosis of acute type A aortic dissection.

Main Methods:

  • Retrospective collection of 361 patients who underwent AAAD surgery.
  • Patients divided into three groups based on baseline TG/HDL-C ratio tertiles.
  • Kaplan-Meier survival analysis, Cox proportional hazards regression, and ROC curve analysis were employed.

Main Results:

  • In-hospital mortality was 22.7% among the 361 patients.
  • Kaplan-Meier analysis revealed a gradual increase in in-hospital death risk with higher TG/HDL-C ratios (P < 0.001).
  • Multivariate Cox regression identified TG/HDL-C ratio as a significant positive predictor of in-hospital mortality (HR = 1.472, P = 0.019) after adjusting for other risk factors.

Conclusions:

  • Patients with AAAD exhibit significant abnormalities in blood lipid metabolism.
  • Serum TG/HDL-C levels are positively correlated with in-hospital mortality in AAAD patients.
  • The TG/HDL-C ratio may serve as a valuable prognostic indicator for AAAD.
Abstract

Keywords:
In-hospital mortalityOutcomeTG/HDL-C ratioType A acute aortic dissection

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