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Related Experiment Video

Updated: Sep 2, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Long COVID headache.

Claudio Tana1, Enrico Bentivegna2, Soo-Jin Cho3

  • 1Center of Excellence On Headache, Geriatrics and COVID-19 Clinic, SS Annunziata Hospital of Chieti, 66100, Chieti, Italy. claudio.tana@asl2abruzzo.it.

The Journal of Headache and Pain
|August 1, 2022
PubMed
Summary
This summary is machine-generated.

Headache is a common long COVID symptom, presenting as new or worsened primary headaches. Research is defining its characteristics, mechanisms, and treatment, often guided by existing primary headache protocols.

Keywords:
Coronavirus disease-19DiagnosisHeadacheMigraineMorbidityPainSARS-CoV-2

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Headache Medicine

Background:

  • Headache is a frequent post-COVID-19 symptom, part of long COVID.
  • Limited knowledge exists on long COVID headache features, pathophysiology, and treatment.

Purpose of the Study:

  • To summarize current evidence on long COVID headache.
  • To suggest diagnostic and treatment approaches for this condition.

Main Methods:

  • Literature review of recent evidence on long COVID headache.
  • Synthesis of clinical characteristics, potential mechanisms, and treatment recommendations.

Main Results:

  • Long COVID headache can be a new onset or exacerbation of pre-existing headaches.
  • Common phenotypes include migrainous and tension-type-like headaches, often with hyposmia.
  • Immune system and trigeminovascular activation are implicated in its pathophysiology.

Conclusions:

  • Long COVID headache is a distinct entity requiring further research.
  • Diagnosis and treatment currently rely on primary headache guidelines.
  • Understanding its features is crucial for effective patient management.