Related Experiment Video
Updated: Sep 2, 2025
13:19
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
16.7K
Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus
Min Yang1, Kailv Sun1, Jianmin Chang2
1Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Biomedical Engineering Online
|August 1, 2022
Summary
Circular RNAs (circRNAs) show abnormal regulation in vulvar lichen sclerosus (VLS). This study identified differentially expressed circRNAs, suggesting their role in VLS pathogenesis and disease progression.
Area of Science:
- Gynecology
- Molecular Biology
- Genetics
Background:
- Vulvar lichen sclerosus (VLS) is a common vulvar condition affecting women.
- Thirteen percent of women experience symptomatic vulvar diseases.
Purpose of the Study:
- To investigate the expression profile of circular RNAs (circRNAs) in VLS tissues.
- To identify core genes involved in the pathogenesis of VLS.
Main Methods:
- RNA sequencing was performed on 20 VLS tissue samples and 20 healthy vulvar skin samples after rRNA removal.
- Differential expression analysis was conducted for messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), and circRNAs.
- Bioinformatics analysis was employed to explore the potential functions of differentially expressed RNAs.
Main Results:
- A total of 79 differentially expressed circRNAs were identified in VLS, with 54 up-regulated and 25 down-regulated.
- Differentially expressed circRNAs were associated with biological processes and molecular functions.
- Key signaling pathways implicated include "human T-cell leukemia virus 1 infection" and "axon guidance".
Conclusions:
- An abnormal circRNA expression profile is characteristic of VLS.
- Dysregulation of circRNAs is potentially linked to the pathogenesis and pathological processes of VLS.
