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New Perspectives on Antimicrobial Agents: Maribavir.
Virginie Halpern-Cohen1, Emily A Blumberg1
1Department of Medicine, Division of Infectious Diseases, Ruth and Raymond Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Antimicrobial Agents and Chemotherapy
|August 2, 2022
Summary
Maribavir offers a new oral treatment for refractory cytomegalovirus (CMV) infections post-transplant. It shows efficacy and a better safety profile than older therapies for resistant CMV disease.
Area of Science:
- Virology
- Pharmacology
- Transplantation Medicine
Background:
- Post-transplant cytomegalovirus (CMV) infection/disease is a significant complication.
- Existing therapies for refractory CMV are limited by resistance and side effects.
- Maribavir represents a novel therapeutic option for managing resistant CMV.
Purpose of the Study:
- To review the chemistry and clinical pharmacology of maribavir.
- To summarize clinical efficacy, safety, and tolerability data of maribavir.
- To discuss resistance patterns associated with maribavir therapy.
Main Methods:
- Review of published clinical trial data and scientific literature.
- Analysis of maribavir's mechanism of action and pharmacokinetic properties.
- Evaluation of safety, efficacy, and resistance data from clinical studies.
Main Results:
- Maribavir is an oral benzimidazole riboside with potent, selective anti-CMV activity.
- It demonstrates efficacy in treating refractory CMV infections, including those with genotypic resistance.
- Maribavir exhibits a more favorable safety profile compared to traditional anti-CMV agents.
Conclusions:
- Maribavir is approved for refractory CMV infections in transplant recipients.
- Its novel mechanism of action provides an alternative for resistant cases.
- The drug offers a promising therapeutic advance with improved tolerability.
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