Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Assessment of the Rectum and Anus

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...

Comparing the Survival Analysis of Two or More Groups

Comparing the Survival Analysis of Two or More Groups

Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phosphatidic Acid Reverses Obesity Induced by a High-Fat, High-Sugar Diet at the Transcriptional Level.

Genes·2025

Same author

Physiotherapy Reduces Pain and Alters Fatty Acid Biomarkers in Women with Chronic Non-Specific Low Back Pain.

International journal of women's health·2025

Same author

The Impact of Patient, Disease, and Social Determinants of Health on Receipt of Nonoperative Management for Patients With Rectal Adenocarcinoma.

American journal of clinical oncology·2025

Same author

The immediate effect of anodal tDCS over the motor cortex on postural control and cortical activation in patients with chronic low back pain: A preliminary study.

Behavioural brain research·2025

Same author

Aluminum nitride photonics for high-speed electro-optical tuning of self-injection-locked laser.

Optics letters·2025

Same author

Tumor microenvironment and Fe<sup>3+</sup>-triggered croconium nanoplatform for precise tumor location and combined type I photodynamic and photothermal amplified therapy.

Journal of colloid and interface science·2025

Search research articles

Related Experiment Video

Updated: Sep 2, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Neoadjuvant rectal score is prognostic for survival: A population-based propensity-matched analysis.

Samer A Naffouje¹, Nicholas Manguso¹, Iman Imanirad¹

¹Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Journal of Surgical Oncology

|August 2, 2022

Summary

The Neoadjuvant Rectal (NAR) score effectively predicts long-term survival in rectal cancer patients treated with neoadjuvant chemoradiation. This score is a reliable indicator of overall survival, irrespective of adjuvant chemotherapy.

Keywords:

NAR score NCDB overall survival rectal adenocarcinoma surrogate endpoint

More Related Videos

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

Related Experiment Videos

Last Updated: Sep 2, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

Area of Science:

Oncology
Clinical Trials
Cancer Research

Background:

The Neoadjuvant Rectal (NAR) score is being evaluated as a surrogate endpoint for overall survival (OS) in clinical trials.
This study validates the NAR score's utility using a large national cancer registry.

Purpose of the Study:

To assess the Neoadjuvant Rectal (NAR) score as a predictor of overall survival (OS) in patients with locally advanced rectal adenocarcinoma.
To determine if the NAR score's predictive value is independent of adjuvant chemotherapy (AC) receipt.

Main Methods:

Utilized the National Cancer Database for patients with clinical stage II/III rectal adenocarcinoma (RAC) undergoing neoadjuvant chemoradiation (CRT) and surgery.
Categorized patients into low-, intermediate-, and high-NAR score subgroups and analyzed overall survival (OS) using Kaplan-Meier and logistic regression.
Employed propensity-matched analysis to compare OS outcomes between NAR subgroups, both with and without adjuvant chemotherapy (AC).

Main Results:

A total of 12,452 patients were analyzed; 15.2% achieved a pathologic complete response.
Significant differences in 5-year OS were observed across NAR subgroups (p < 0.001), both with (93% vs. 88% vs. 75%) and without (85% vs. 76% vs. 68%) adjuvant chemotherapy.
Logistic regression confirmed NAR strata as a significant predictor of 5-year OS.

Conclusions:

The Neoadjuvant Rectal (NAR) score is a robust predictor of 5-year overall survival in locally advanced rectal cancer.
The NAR score's predictive capability for overall survival is maintained regardless of adjuvant chemotherapy administration.
The NAR score serves as a valuable neoadjuvant response measure for clinical trial endpoints in heterogeneous rectal cancer populations.