Related Experiment Video
Updated: Sep 2, 2025
Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
Avoiding Unnecessary Biopsy after Multiparametric Prostate MRI with VERDICT Analysis: The INNOVATE Study
Saurabh Singh1, Harriet Rogers1, Baris Kanber1
1From the Centre for Medical Imaging, Division of Medicine (S.S., H.R., J.C., E.W.J., T.P., D.A., S.P.), Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering (B.K.), Molecular Diagnostics and Therapeutics Group (H.P., S.H., U.S.F., H.C.W.), Division of Surgery and Interventional Sciences (F.G., C.M.M.), and Centre for Medical Image Computing, Department of Computer Science (D.C.A., E.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, England; Department of Diagnostic Radiology, Royal Marsden Hospital, London, England (E.W.J.); Departments of Urology (A.G., E.D., G.S., C.M.M.), Pathology (A.H., A.F.), and Radiology (F.G.), University College London Hospitals NHS Foundation Trust, London, England; and Department of Urology, Barts Health, NHS Foundation Trust, London, England (A.G., G.S.).
Fractional intracellular volume (FIC) from Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumor (VERDICT) MRI better identifies clinically significant prostate cancer (csPCa) than apparent diffusion coefficient (ADC) or prostate-specific antigen density (PSAD). This improves diagnostic accuracy for men with suspicious MRI findings.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Up to 50% of men with positive multiparametric MRI (mpMRI) findings for prostate cancer (PCa) lack clinically significant disease upon biopsy.
- Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumor (VERDICT) MRI offers potential for improved stratification of mpMRI findings.
Purpose of the Study:
- To evaluate VERDICT MRI-derived fractional intracellular volume (FIC), mpMRI-derived apparent diffusion coefficient (ADC), and prostate-specific antigen density (PSAD) in determining clinically significant PCa (csPCa).
Main Methods:
- Prospective study of 165 biopsy-naive men with suspected PCa undergoing VERDICT MRI and mpMRI.
- Comparison of lesion ADC, FIC, and PSAD between men with and without csPCa using nonparametric tests and ROC curve analysis.
Main Results:
- Median lesion FIC was significantly higher in men with csPCa across Likert 3 and 4 lesions (P < .001).
- Lesion ADC was lower in csPCa for Likert 4 lesions (P = .03) but not Likert 3.
- PSAD showed no significant difference between groups for either Likert score.
- FIC demonstrated superior diagnostic performance (AUC, 0.96) compared to ADC (AUC, 0.85) and PSAD (AUC, 0.74) for detecting csPCa.
Conclusions:
- Lesion fractional intracellular volume (FIC) derived from VERDICT MRI is a more effective classifier of clinically significant prostate cancer than ADC and PSAD.
- VERDICT MRI analysis holds promise for improving the diagnostic accuracy in men with suspicious mpMRI findings for prostate cancer.
More Related Videos
06:08A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
05:49Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
Published on: October 10, 2019
