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Updated: Sep 2, 2025
08:03
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
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PanExplorer: a web-based tool for exploratory analysis and visualization of bacterial pan-genomes
Alexis Dereeper1,2, Marilyne Summo2,3, Damien F Meyer1
1CIRAD, UMR ASTRE, F-97170 Petit-Bourg, France.
Bioinformatics (Oxford, England)
|August 2, 2022
Summary
PanExplorer is a new web tool that simplifies bacterial pan-genome exploration for biologists. It offers intuitive visualizations and genomic analyses, making complex data accessible.
Area of Science:
- Microbiology
- Genomics
- Bioinformatics
Background:
- Pan-genome analysis is crucial for understanding bacterial comparative genomics and evolution.
- Current pan-genome approaches are often complex and inaccessible to non-bioinformatician biologists.
Purpose of the Study:
- To develop an innovative and user-friendly tool for exploring bacterial pan-genomes.
- To provide intuitive genomic analyses and visualizations for a better understanding of bacterial genomic diversity.
Main Methods:
- Development of PanExplorer, a web application utilizing Perl CGI.
- Integration of JavaScript libraries (hotmap.js, MauveViewer, CircosJS) for data visualization.
- Application of the tool to generate the pan-genome for 121 Anaplasmataceae strains.
Main Results:
- PanExplorer provides accessible genomic analyses and reports.
- Intuitive visualizations facilitate a deeper understanding of bacterial pan-genomes.
- The pan-genome of 121 Anaplasmataceae strains (Ehrlichia, Anaplasma, Wolbachia) was successfully generated.
Conclusions:
- PanExplorer effectively addresses the need for an accessible bacterial pan-genome exploration tool.
- The application empowers biologists to conduct advanced genomic analyses without extensive bioinformatics expertise.
- PanExplorer is freely available, promoting wider adoption in bacterial research.
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