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Published on: November 9, 2019
The complete mechanism of an aldol condensation in water
1Dept. of Chemistry & Biochemistry, Univ. Calif. San Diego, La Jolla, CA, 92093-0358, USA. cperrin@ucsd.edu.
Abstract:
The base-catalyzed aldol condensation between benzaldehyde and p-acetylbenzoic acid in water shows an inverse solvent kinetic isotope effect, k3,D/k3,H, of 1.33 ± 0.03. The reaction is definitely faster in D2O. This is interpreted to mean that the rate-limiting step in a five-step mechanism is Step 5, the final elimination of hydroxide from the enolate intermediate, not the formation of that intermediate. This is the same result and the same conclusion as from earlier studies in aqueous acetonitrile and refutes a suggestion, based on computations, that the rate-limiting step would change in water. Those computations are criticized as implying impossibly large isotope effects.
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The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...

