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The relationship between complete hydatidiform mole and serum Vitamin D level: a prospective case-control study
1Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. ryhn.gunduz@gmail.com.
European Review for Medical and Pharmacological Sciences
|August 2, 2022
Summary
This study found no link between Vitamin D levels and complete hydatidiform mole (CHM). Vitamin D deficiency is not a risk factor for CHM, regardless of obesity status.
Area of Science:
- Reproductive endocrinology and metabolism.
Background:
- Complete hydatidiform mole (CHM) is a pregnancy complication.
- The role of Vitamin D in CHM pathogenesis is not well understood.
Purpose of the Study:
- To investigate the relationship between serum Vitamin D levels and CHM.
- To determine if Vitamin D deficiency is a risk factor for CHM.
Main Methods:
- A prospective study comparing 30 CHM patients with 30 healthy pregnant women and 30 non-pregnant women.
- Serum 25-hydroxyvitamin D (25-OH D) levels were measured and compared across groups.
- Demographic and obstetric factors including BMI, gravida, parity, and abortus history were recorded.
Main Results:
- The average serum 25-OH D level was 11.16±8.64 ng/mL across all participants.
- No significant differences in 25-OH D levels were observed between CHM patients and control groups.
- Obesity status did not significantly alter the relationship between Vitamin D levels and CHM.
Conclusions:
- Serum Vitamin D deficiency, insufficiency, or severe deficiency are not identified as risk factors for CHM.
- These findings suggest Vitamin D status does not play a significant role in the development of CHM.
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