Related Experiment Video

Updated: Aug 11, 2026

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
11:26

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung

Published on: July 18, 2016

Chronic lung disease in infants with very low birth weight. A population-based study

E N Kraybill, C L Bose, A J D'Ercole

    American Journal of Diseases of Children (1960)
    |July 1, 1987
    PubMed

    Insights

    Chronic lung disease (CLD) affected 39% of ventilated very-low-birth-weight infants at 30 days, decreasing over time. Incidence varied significantly among newborn intensive care units (NICUs).

    Area of Science:

    • Neonatology
    • Pediatric Pulmonology
    • Public Health

    Background:

    • Chronic lung disease (CLD) is a significant concern for very-low-birth-weight (VLBW) infants.
    • Understanding the incidence and variations in CLD is crucial for improving outcomes in neonatal intensive care units (NICUs).

    Purpose of the Study:

    • To determine the incidence of CLD in VLBW infants born in North Carolina in 1984.
    • To investigate potential differences in CLD incidence among various NICUs.
    • To explore factors influencing CLD rates, including mechanical ventilation duration and birth weight.

    Main Methods:

    • A survey of 1095 (95.5%) of 1147 VLBW infants born in North Carolina in 1984.
    • Assessment of respiratory support (mechanical ventilation, oxygen dependence) at 30 days, 3 months, and 6 months of age.
    • Analysis of CLD incidence variations across different NICUs, considering infant weight distribution and treatment practices.

    Main Results:

    • At 30 days, 39% of surviving infants on mechanical ventilation >48 hours were respirator dependent; 15% were oxygen dependent.
    • By 6 months, respirator dependence was 1.6%, oxygen dependence was 3%, and mortality was 9%.
    • Significant variations in CLD incidence were observed among NICUs, not directly related to patient volume or resident-led treatment; incidence varied inversely with birth weight.

    Conclusions:

    • CLD incidence in VLBW infants decreases significantly between 30 days and 6 months of age.
    • Substantial variations in CLD rates exist among NICUs, suggesting potential differences in care practices.
    • Birth weight is a factor in CLD incidence, but NICU-specific differences persist even after accounting for weight distributions.

    More Related Videos

    Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

    Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

    Published on: March 6, 2019

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

    Published on: October 31, 2025

    Related Concept Videos

    Breathing01:05

    Breathing

    The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
    Chronic Obstructive Pulmonary Disease01:24

    Chronic Obstructive Pulmonary Disease

    COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
    Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
    Chronic Obstructive Pulmonary Disease-I: Introduction01:20

    Chronic Obstructive Pulmonary Disease-I: Introduction

    Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
    Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

    Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

    Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
    Medical History
    Chronic Obstructive Pulmonary Disease I: Introduction01:23

    Chronic Obstructive Pulmonary Disease I: Introduction

    Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
    Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

    Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

    Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...