Related Experiment Video
Updated: Sep 2, 2025
07:17
Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions
Published on: January 19, 2024
2.0K
Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea.
Emily S Sagalow1, Ashwin Ananth1, Rahul Alapati1
1Department of Sleep Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
The American Journal of Cardiology
|August 2, 2022
Summary
The RespiCardia remedē System effectively treats central sleep apnea (CSA) by stimulating the phrenic nerve, improving sleep and quality of life with few complications in adult patients.
Area of Science:
- Medical Devices
- Respiratory Medicine
- Sleep Medicine
Background:
- Central sleep apnea (CSA) negatively impacts quality of life and cardiovascular health.
- Phrenic nerve stimulation offers a potential therapeutic approach for CSA.
Purpose of the Study:
- To systematically review the evidence on the RespiCardia remedē System for treating central sleep apnea.
- To summarize patient selection, complications, adherence, and efficacy of the remedē System.
Main Methods:
- Systematic review adhering to PRISMA guidelines.
- Searched PubMed/MEDLINE, Cochrane, CINAHL, and Ovid databases (2000-2021).
- Included 13 studies involving 232 patients implanted with the remedē System.
Main Results:
- Significant reductions in central apnea index observed across studies.
- Many patients reported mild to marked improvements in quality of life.
- Few immediate or delayed complications were reported.
Conclusions:
- The remedē System is a safe and effective treatment for moderate to severe CSA in adults.
- The device improves sleep and respiratory parameters, including in patients with heart failure.
- Phrenic nerve stimulation demonstrates positive outcomes for CSA management.
Related Concept Videos
01:21Sleep Apnea
216
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
216
01:25Hyperpnea and Hyperventilation
1.3K
Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
1.3K