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Related Experiment Videos

Amniocentesis before 15 weeks' gestation: outcome, risks, and technical problems.

F W Hanson, E M Zorn, F R Tennant

    American Journal of Obstetrics and Gynecology
    |June 1, 1987
    PubMed
    Summary
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    Early amniocentesis before 15 weeks is a safe procedure with a low postprocedural loss rate of 4.7%. Excluding patients with prior bleeding history, the rate further decreases to 3.3%.

    Area of Science:

    • Perinatal Medicine
    • Maternal-Fetal Medicine
    • Obstetrics

    Background:

    • Amniocentesis is a common prenatal diagnostic procedure.
    • Early amniocentesis, performed before 15 weeks gestation, is less studied.
    • Assessing the safety and outcomes of early amniocentesis is crucial for clinical practice.

    Purpose of the Study:

    • To evaluate the safety and pregnancy outcomes of early amniocentesis.
    • To compare outcomes between transplacental and nontransplacental needle insertions.
    • To determine the postprocedural loss rate associated with early amniocentesis.

    Main Methods:

    • Retrospective review of 4750 amniocenteses performed between 1979 and 1986.
    • Identification of 541 early amniocenteses (before 15 weeks gestation).

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  • Analysis of maternal age, indications, ultrasound findings, needle insertion site, fluid color, test results, complications, and pregnancy outcomes for 298 subjects with complete follow-up.

    • Main Results:

    • The overall postprocedural loss rate was 4.7% (14/298), including miscarriage, stillbirth, and neonatal death.
    • Excluding patients with a history of bleeding, the loss rate decreased to 3.3% (7/211).
    • No significant difference in pregnancy outcome was observed between transplacental and nontransplacental amniocentesis.

    Conclusions:

    • Early amniocentesis, even before 15 weeks, demonstrates a low and acceptable postprocedural loss rate.
    • The procedure appears safe regardless of needle insertion location (transplacental vs. nontransplacental).
    • Further research may be warranted to confirm findings in contemporary practice.