Assessment of angiographic retinal capillary nonperfusion in central retinal vein occlusion

We studied the reproducibility and accuracy of eight retinal specialists in assessing the extent of retinal capillary nonperfusion on fluorescein angiograms of 26 central retinal vein occlusions. Each specialist was asked to classify the retinal capillary perfusion status on every angiogram as nonischemic, minimally ischemic, moderately ischemic, markedly ischemic, or uncertain. Criteria for classification of each angiogram were specified in advance for each reviewer. Each examiner individually reviewed every angiogram on two separate occasions separated by at least one month. Intraexaminer and interexaminer reproducibility were both substantially better than the agreement predicted by chance alone (P less than .05); however, the proportion of agreement with the correct classification was less than 60% for all eight specialists.