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Related Concept Videos

Photoluminescence: Applications01:14

Photoluminescence: Applications

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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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Photoluminescence: Fluorescence and Phosphorescence01:23

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Photoluminescence is a process where a molecule absorbs light energy and re-emits it in the form of light. This phenomenon occurs when a substance absorbs photons, promoting its electrons to higher energy level excited states, followed by a relaxation process in which the electrons return to their original ground state energy levels and emit light. Photoluminescence is widely observed in various materials, including semiconductors, and organic and inorganic compounds.
A pair of electrons in a...
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Luminescence Lifetime Imaging Based on Lanthanide Nanoparticles.

Xinyan Zhu1, Xiaohan Wang1, Hongxin Zhang1

  • 1Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, China.

Angewandte Chemie (International Ed. in English)
|August 2, 2022
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Summary

Luminescence lifetime imaging using lanthanide-doped nanoparticles (LnNPs) offers precise detection by leveraging long-lived luminescence. This technique enhances signal-to-noise ratio and allows for tunable lifetimes in advanced imaging systems.

Keywords:
Lanthanide NanoparticlesLifetime ImagingLuminescence LifetimeMultiplexing DetectionSensors

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Area of Science:

  • Optics and Photonics
  • Materials Science
  • Biomedical Imaging

Background:

  • Luminescence lifetime imaging provides superior quantification over traditional methods due to stable luminescence lifetimes.
  • Lanthanide-doped nanoparticles (LnNPs) are gaining attention for their long-lived luminescence properties.
  • Long luminescence lifetimes aid in background signal reduction and offer tunable imaging parameters.

Purpose of the Study:

  • To review the luminescence mechanisms of LnNPs.
  • To discuss strategies for modulating luminescence lifetime.
  • To explore applications of LnNPs in lifetime imaging systems.

Main Methods:

  • Review of luminescence mechanisms in LnNPs.
  • Analysis of luminescence lifetime modulation strategies.
  • Compilation of data acquisition methods for lifetime imaging.
  • Survey of current applications in lifetime imaging.

Main Results:

  • LnNPs exhibit long luminescence lifetimes beneficial for imaging.
  • Strategies for tuning luminescence lifetime are presented.
  • Various applications of lifetime imaging with LnNPs are highlighted.

Conclusions:

  • Luminescence lifetime imaging with LnNPs presents significant advantages for precise quantification.
  • Further research into LnNP technologies can enhance imaging capabilities and expand applications.