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Management of cataract surgery in Lowe syndrome

Katharina Eibenberger1, Sandra Rezar-Dreindl1, Franz Pusch2

  • 1Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna 1090, Austria.

International Journal of Ophthalmology
|August 3, 2022
PubMed

Insights

Bilateral cataract surgery in children with Lowe syndrome is safe under general anesthesia. Regular glaucoma screening is vital to prevent vision loss in these patients.

Area of Science:

  • Ophthalmology
  • Pediatric Surgery
  • Genetics

Background:

  • Lowe syndrome is a rare genetic disorder affecting multiple organs, including the eyes.
  • Cataract surgery in children with Lowe syndrome requires careful ophthalmic and anesthesiologic management.
  • Secondary glaucoma is a potential complication following cataract surgery in this population.

Purpose of the Study:

  • To evaluate the safety and efficacy of ophthalmic and anesthesiologic management during cataract surgery in children with Lowe syndrome.
  • To assess the development and management of secondary glaucoma post-cataract surgery in these patients.

Main Methods:

  • Retrospective case series of 12 eyes from 6 children with genetically verified Lowe syndrome undergoing cataract removal.
  • Data collected included surgical details, anesthesia time, and intra/postoperative complications.
  • Clinical examinations included visual acuity and funduscopy.

Main Results:

  • All children underwent simultaneous bilateral cataract surgery under general anesthesia.
  • Lensectomy with posterior capsulotomy and anterior vitrectomy was performed in all cases.
  • Common postoperative findings included nystagmus and strabismus; no visual axis opacification occurred. Secondary glaucoma developed in 5 eyes (3 children), requiring surgical intervention in some cases.

Conclusions:

  • Simultaneous bilateral cataract surgery under general anesthesia is a safe procedure for children with Lowe syndrome.
  • Postoperative glaucoma screening and intraocular pressure monitoring are essential for managing Lowe syndrome patients and preventing further visual impairment.
Abstract

Keywords:
Lowe syndromecongenital cataractpediatric cataract surgery

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