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Published on: August 15, 2019
Adams-Oliver Syndrome: Vestigial Tail and Genetics Update
Victor Z Zhu1, Emily Hansen-Kiss2,3, Jacqueline T Hecht2,4,3
1Division of Plastic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, Texas.
Abstract:
Adams-Oliver syndrome is a well-recognized autosomal dominant disorder for which mutations in six genes are etiologic, but account for only one-third of the cases. We report a patient with two genetic disorders; Adams-Oliver and Xp22.33 deletion syndromes, as well as a vestigial pseudotail. The presence of a pseudotail has not previously been reported in either of these genetic conditions. Absence of a molecular etiology underlying Adams-Oliver syndrome confirms that there are additional genetic causes to be identified.
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