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Clinical parameters in different stages, zones, and remission/progression statuses of retinopathy of prematurity
Seyed Ahmad Rasoulinejad1, Faezeh Maroufi2, Ahad Alizadeh3
1Department of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Insights
Clinical laboratory parameters differ in premature infants with retinopathy of prematurity (ROP). Hemoglobin, bilirubin, and BUN levels vary significantly with ROP stages, zones, and progression, impacting visual impairment outcomes.
Area of Science:
- Ophthalmology
- Neonatology
- Clinical Chemistry
Background:
- Retinopathy of prematurity (ROP) is a severe vasoproliferative retinal disease affecting premature infants, leading to lifelong visual impairment and blindness.
- Understanding ROP's clinical and biochemical markers is crucial for early diagnosis and management.
Purpose of the Study:
- To investigate differences in clinical laboratory parameters among premature infants based on ROP status, including stages, zones, and remission/progression.
- To identify specific hematological and biochemical markers associated with ROP severity and its clinical course.
Main Methods:
- A historical cohort study involving 828 premature infants, categorized into ROP and control groups.
- Collection and analysis of biochemical and hematological parameters from patient histories.
Main Results:
- Infants with ROP showed significantly lower levels of hemoglobin, total bilirubin, potassium, and calcium compared to controls.
- ROP patients exhibited higher reticulocyte percentages and BUN levels than controls.
- Hemoglobin and BUN levels differed significantly across ROP zones; hemoglobin, total bilirubin, and CRP were higher in reduced ROP stages.
Conclusions:
- Clinical laboratory parameters exhibit distinct values across different stages, zones, and remission/progression statuses in infants with ROP.
- These findings highlight the potential of laboratory markers in assessing ROP severity and predicting its course.
Background:
Retinopathy of prematurity (ROP) is a vasoproliferative retinal disease in premature infants that causes lifetime visual impairment and blindness in the early ages. In this study, we investigated the differences in the values of clinical laboratory parameters between different ROP and its remission/progression statuses regarding stages and zones.
Methods:
This historical cohort study includes 828 infants divided into two groups after the first examination containing ROP infants and controls. The biochemical and hematological parameters of the two groups have been collected from the patient's history.
Results:
In infants with ROP, the hematopoiesis-related parameters, including the mean level of hemoglobin, total bilirubin, potassium, calcium were significantly less than controls (P=0.039, P=0.001, P=0.001, and P=0.046, respectively). The percentages of reticulocyte and the levels of BUN in ROP patients were significantly higher than in normal infants (P=0.015 and p <0.001, respectively). Moreover, the levels of hemoglobin and BUN were significantly different in the different zones of ROP (P=0.017 and P=0.001, respectively). Also, higher hemoglobin levels, total bilirubin, and CRP were observed in the reduced stages of ROP (P=0.041, P=0.045, and P=0.039, respectively).
Conclusion:
Laboratory parameters are different in different stages, zones and remission/ progression ROP infants.
