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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Hemodialysis II: Procedure and Complications01:24

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DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Hepatic Portal System01:21

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
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Updated: Sep 2, 2025

New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation
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Statin-Induced Rhabdomyolysis Associated With Transjugular Intrahepatic Portosystemic Shunt Placement.

Eric C Swei1, Anantnoor K Brar2, Jonathan D Rice1

  • 1Division of Gastroenterology, University of Colorado School of Medicine, Aurora, CO.

ACG Case Reports Journal
|August 3, 2022
PubMed
Summary

Statin-induced rhabdomyolysis, a rare but lethal condition, can be worsened by cirrhosis. Transjugular intrahepatic portosystemic shunt placement may further increase this risk, as seen in a recent case report.

Area of Science:

  • Hepatology
  • Pharmacology
  • Toxicology

Background:

  • Rhabdomyolysis is a rare, potentially lethal complication associated with statin therapy.

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  • Hepatic dysfunction, particularly in patients with cirrhosis, can potentiate the toxic effects of statins.
  • Transjugular intrahepatic portosystemic shunt (TIPS) placement alters hepatic physiology, potentially impacting drug metabolism and toxicity.