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Related Experiment Video

Updated: Sep 2, 2025

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
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[When a Gap Leads to an Answer].

Svenja Pelz1, Ulrich Gerwig1, Sonia Frick1

  • 1Institut für Notfallmedizin, Spital Limmattal, Schlieren, Schweiz.

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|August 3, 2022
PubMed
Summary
This summary is machine-generated.

A young adult ingested ethylene glycol antifreeze, leading to severe metabolic acidosis and elevated lactate levels. This case highlights a critical poisoning scenario requiring prompt medical intervention.

Keywords:
Ethylene glycolEthylenglykolFomepizolfomepizolehigh anion gap metabolic acidosisumetabolische Azidose mit erweiterter Anionenlücke

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Area of Science:

  • Toxicology
  • Internal Medicine
  • Emergency Medicine

Background:

  • Ethylene glycol poisoning is a potentially fatal condition often resulting from accidental or intentional ingestion.
  • Early recognition and management are crucial for patient survival and preventing long-term complications.

Observation:

  • A 22-year-old patient presented with somnolence, nausea, abdominal pain, and vomiting.
  • Clinical examination revealed altered mental status consistent with severe systemic compromise.

Findings:

  • Laboratory analysis indicated high anion gap metabolic acidosis, a hallmark of toxic ingestions.
  • Elevated lactate levels (lactatemia) were observed, suggesting tissue hypoperfusion or metabolic derangement.

Implications:

  • This case underscores the importance of considering ethylene glycol poisoning in patients with unexplained metabolic acidosis and altered mental status.
  • Prompt diagnosis and treatment, including supportive care and potential antidotal therapy, are vital for managing ethylene glycol toxicity.
  • Public health awareness regarding the dangers of antifreeze ingestion is essential to prevent such incidents.