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Functional and Morphological Changes Associated with Burst Wave Lithotripsy-Treated Pig Kidneys.
Bret A Connors1, Tony Gardner1, Ziyue Liu2
1Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Journal of Endourology
|August 3, 2022
Summary
Burst wave lithotripsy (BWL) shows no immediate negative effects on kidney function or tissue. This noninvasive urinary stone treatment did not cause functional changes or measurable hemorrhage in pigs.
Area of Science:
- Nephrology
- Urology
- Biomedical Engineering
Background:
- Burst wave lithotripsy (BWL) is an emerging noninvasive technique for urinary stone comminution.
- Concerns exist regarding potential renal injury, but functional changes post-BWL are not well understood.
Purpose of the Study:
- To investigate the acute functional and morphological effects of clinical Burst wave lithotripsy (BWL) on kidney health.
Main Methods:
- Twelve female pigs underwent renal clearance assessment.
- Six pigs received sham treatment, while six were exposed to BWL (18,000 pulses, 12/-7 MPa).
- Glomerular filtration rate (GFR) and effective renal plasma flow (eRPF) were measured pre- and post-treatment, alongside lesion size analysis.
Main Results:
- No gross hematuria was observed in urine samples from treated kidneys.
- BWL treatment did not alter GFR or eRPF measurements.
- No significant hemorrhagic lesions were detected in kidney tissue post-treatment.
Conclusions:
- Clinical Burst wave lithotripsy (BWL), under the parameters used, does not induce acute changes in renal function.
- BWL treatment did not result in measurable hemorrhagic injury to the kidney in this porcine model.
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