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[Platelet variation coefficient and its prognostic value in acute pancreatitis]
V A Mariyko1, M A Shlyakhova1, A V Mariyko1
1Tula State University, Tula, Russia.
Khirurgiia
|August 3, 2022
Summary
Platelet variation coefficient (PVC) can predict acute pancreatitis (AP) severity. Changes in platelet count, size, and distribution, identified early, indicate severe AP and correlate with IL-6 levels.
Area of Science:
- Hematology
- Gastroenterology
- Critical Care Medicine
Background:
- Acute pancreatitis (AP) is a serious condition with variable severity.
- Predicting AP severity is crucial for timely and appropriate management.
- Current predictive markers may lack sensitivity or specificity.
Purpose of the Study:
- To evaluate the role of platelet variation coefficient (PVC) in predicting the severity of acute pancreatitis (AP).
Main Methods:
- A cohort of 90 AP patients was analyzed.
- Platelet count, volume, thrombocytocrit, and volume-adjusted distribution were assessed.
- Parameters were measured at multiple time points post-admission (days 1-35).
Main Results:
- Significant correlations were found between AP severity and platelet parameters.
- Reduced platelet count, enlarged platelets, and heterogeneous platelet volumes indicated severe AP.
- Platelet variation coefficient (PVC) emerged as a predictor of AP severity, correlating with IL-6.
Conclusions:
- The proposed PVC is a readily available and simple tool for predicting AP severity.
- PVC allows for early assessment of pancreatitis course and treatment effectiveness within three days.
- Incorporating PVC can enhance the prediction of AP outcomes.
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