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COVID-19 imparted immune manifestation can be combated by NLGP: Lessons from cancer research

Anamika Bose1, Rathindranath Baral1

  • 1Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India.

Cytokine
|August 3, 2022
PubMed

Insights

Neem Leaf Glycoprotein (NLGP) may restore immune cell function in SARS-CoV-2 infections. This could help generate effective T cells and combat virus-associated lymphopenia.

Area of Science:

  • Immunology
  • Virology
  • Biochemistry

Background:

  • SARS-CoV-2 infects immune cells like monocytes, macrophages, and dendritic cells (DCs).
  • This infection causes antigen-presenting cell (APC) dysfunction, leading to T cell anergy, exhaustion, and apoptosis.
  • These immune dysfunctions contribute to lymphopenia observed in SARS-CoV-2 infections.

Purpose of the Study:

  • To investigate the potential of Neem Leaf Glycoprotein (NLGP) in correcting SARS-CoV-2-induced immune cell dysfunction.
  • To explore NLGP's role in restoring T cell-mediated immunity and generating SARS-CoV-2-specific T cells.

Main Methods:

  • The study focuses on the known effects of NLGP on DC functions, drawing parallels from cancer research.
  • It hypothesizes NLGP's ability to correct altered DC functions caused by SARS-CoV-2.

Main Results:

  • NLGP has a significant role in modulating DC functions, enhancing T cell-mediated cytotoxicity.
  • NLGP may correct SARS-CoV-2-induced DC alterations, potentially improving antigen presentation.

Conclusions:

  • NLGP holds promise for restoring immune balance in SARS-CoV-2 infections.
  • Targeting DC function with NLGP could be a therapeutic strategy to generate effective SARS-CoV-2-specific T cells and mitigate lymphopenia.
Keywords:
CD8(+) T CellsCOVID-19CancerDendritic CellsIL-6NLGP

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