Symptomatic and severe pulmonary hypertension due to hyperthyroidism

Area of Science:

• Cardiology
• Endocrinology
• Pulmonary Medicine

Background:

• Hyperthyroidism is a known cause of secondary pulmonary hypertension (PH).
• Previous studies suggest PH associated with hyperthyroidism is often asymptomatic and mild.

Observation:

• A woman in her 30s presented with symptomatic, severe PH, including dyspnea and edema.
• Echocardiography revealed severe PH with an estimated pulmonary arterial systolic pressure (ePASP) of 62 mm Hg.

Findings:

• Diagnostic work-up confirmed severe PH directly caused by hyperthyroidism.
• Following treatment for hyperthyroidism, thyroid function normalized, and ePASP decreased to 30 mm Hg.

Implications:

• This case highlights that hyperthyroidism can lead to severe, symptomatic PH.
• Emphasizes the importance of considering and screening for hyperthyroidism in PH patients.
• Early diagnosis and treatment of hyperthyroidism are vital for managing and improving PH.