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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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[Correlation between abnormal left atrial appendage function and thrombotic events in patients with non-valvular

J Q Liu1, M Wei1, Dilare Taiwaikuli1

  • 1Department of Pacing and Electrophysiology, Heart Center, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Key Laboratory of Cardiac Electrophysiology and Cardiac Remodeling, Urumqi 830054, China.

Zhonghua Nei Ke Za Zhi
|August 3, 2022
PubMed

Insights

Abnormal left atrial appendage function significantly increases the risk of thrombotic events in non-valvular atrial fibrillation patients. Key risk factors include larger left atrial diameter and persistent atrial fibrillation.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Diagnostic Imaging

Background:

  • Non-valvular atrial fibrillation (NVAF) poses a significant risk for thrombotic events.
  • The left atrial appendage (LAA) plays a crucial role in clot formation.
  • Understanding LAA function is vital for predicting and preventing thromboembolism.

Purpose of the Study:

  • To examine the link between impaired LAA function and thrombotic events in NVAF patients.
  • To identify independent risk factors influencing LAA function.

Main Methods:

  • Retrospective study of 382 NVAF patients (June 2019-June 2021).
  • Patients categorized by LAA flow velocity (LAAFV): normal (≥40 cm/s) vs. abnormal (<40 cm/s).
  • Transesophageal echocardiography and clinical data analyzed; logistic regression used for correlation analysis.

Main Results:

  • Abnormal LAA function was strongly associated with increased thrombotic events (β=1.168, P=0.002).
  • Independent risk factors for abnormal LAA function identified: increased left atrial diameter (OR=1.084) and persistent atrial fibrillation (OR=2.323).
  • Significant differences noted in various clinical and echocardiographic parameters between groups.

Conclusions:

  • Impaired LAA function is a significant predictor of thrombotic events in NVAF.
  • Left atrial diameter and persistent atrial fibrillation are critical independent risk factors affecting LAA function.

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