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Compensatory thalamocortical functional hyperconnectivity in type 2 Diabetes Mellitus.
Jie Wang1,2,3, Shanlei Zhou4, Datong Deng4
1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, 230022, Hefei, China.
Brain Imaging and Behavior
|August 3, 2022
Summary
Type 2 diabetes (T2DM) patients show altered thalamic connectivity, not volume changes. This functional brain connectivity is linked to better cognition and glucose control, suggesting a compensation mechanism.
Area of Science:
- Neuroscience
- Endocrinology
- Radiology
Background:
- Type 2 diabetes mellitus (T2DM) is linked to brain damage and cognitive decline.
- The thalamus plays a role in cognition and is affected in T2DM, but subregion-level damage is poorly understood.
Purpose of the Study:
- To investigate subregion-level thalamic damage in T2DM patients.
- To explore associations between thalamic structure/function and cognitive performance in T2DM.
Main Methods:
- Collected resting-state functional and structural MRI data from 62 T2DM patients and 50 controls.
- Subdivided the thalamus into 8 subregions per hemisphere, calculating resting-state functional connectivity (rsFC) and gray matter volume (GMV).
Main Results:
- T2DM patients exhibited increased rsFC in medial pre-frontal, posterior parietal, and occipital thalamic subregions.
- Increased thalamic functional hyperconnectivity correlated with better cognitive performance and lower glucose variability in T2DM.
- No significant group differences in GMV were found for any thalamic subregions.
Conclusions:
- T2DM may involve compensatory neural mechanisms, with enhanced thalamocortical functional connectivity potentially preserving cognitive function.
- Better glycemic control appears to facilitate this compensatory hyperconnectivity, impacting cognitive abilities in T2DM.
- Findings may inform interventions for T2DM-related cognitive decline.
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