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Related Experiment Videos

Clinical observations in collies given ivermectin orally.

A J Paul, W J Tranquilli, R L Seward

    American Journal of Veterinary Research
    |April 1, 1987
    PubMed
    Summary

    Collies exhibit a wide sensitivity range to ivermectin toxicosis. Even at high doses, some dogs showed severe reactions, while others tolerated them, indicating individual variability in ivermectin toxicity.

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    Area of Science:

    • Veterinary Pharmacology
    • Toxicology

    Background:

    • Ivermectin is a widely used antiparasitic drug.
    • Collies are known to be sensitive to certain drugs due to genetic factors.

    Purpose of the Study:

    • To evaluate the toxicological effects of ivermectin in purebred Collies.
    • To determine the dose-dependent toxicity of ivermectin in this breed.

    Main Methods:

    • Oral administration of ivermectin to 14 Collies at increasing dosages (100, 200, 600, and 2,500 micrograms/kg).
    • Clinical monitoring for signs of toxicosis, including neurological and systemic effects.
    • Supportive care for dogs experiencing severe toxicosis.

    Main Results:

    • Mild toxicosis observed in 3 dogs at 100 micrograms/kg.

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  • Severe toxicosis (seizures, coma) occurred in 7 dogs at 200 micrograms/kg.
  • No severe toxic signs at 600 micrograms/kg in retreated dogs; only 1 dog showed severe toxicosis at 2,500 micrograms/kg.

    • Conclusions:

    • Collies demonstrate a broad spectrum of sensitivity to ivermectin-induced toxicosis.
    • Individual variability in ivermectin toxicity is significant in this breed.
    • Further investigation into the genetic basis of ivermectin sensitivity in Collies is warranted.