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Updated: Sep 2, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Functional role of miR-34a in diabetes and frailty

Pasquale Mone1,2, Antonio de Donato3, Fahimeh Varzideh1

  • 1Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, United States.

Frontiers in Aging
|August 4, 2022
PubMed

Insights

MicroRNAs (miRNAs) are key in disease. This review highlights miR-34a

Area of Science:

  • Biomedical research
  • Molecular biology
  • Gerontology

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression.
  • Emerging evidence implicates miRNAs in various disease processes.
  • Frailty and diabetes mellitus are significant health concerns, particularly in aging populations.

Purpose of the Study:

  • To review the role of miR-34a in the pathophysiology of frailty.
  • To examine the involvement of miR-34a in diabetes mellitus.
  • To explore miR-34a as a potential biomarker and therapeutic target.

Main Methods:

  • Literature review of current scientific publications.
  • Analysis of existing data on miRNA function in disease.
  • Synthesis of evidence regarding miR-34a's role in frailty and diabetes.

Main Results:

  • miR-34a is implicated in the pathogenesis of both frailty and diabetes mellitus.
  • miR-34a may serve as a potential biomarker for frailty in older adults with diabetes.
  • miR-34a influences oxidative stress pathways relevant to these conditions.

Conclusions:

  • miR-34a is a significant factor in the pathophysiology of frailty and diabetes.
  • This miRNA presents potential as a biomarker for frailty in diabetic elderly individuals.
  • Targeting miR-34a's effects on oxidative stress may offer novel therapeutic strategies.
Keywords:
agingdiabetesfrailtymiR-34miRNA

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