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Editorial: Mesenchymal Stromal Cells: Preclinical and Clinical Challenges

Joan Oliva1, Simone Pacini2, Josep M Canals3

  • 1Department of Clinical Research, Emmaus Life Sciences, Torrance, CA, United States.

Frontiers in Cell and Developmental Biology
|August 4, 2022
PubMed
Summary

No abstract available in PubMed .

Keywords:
GMPMSCcell/gene therapiesregulationstranslational medicine

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Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
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Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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