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Editorial: Mesenchymal Stromal Cells: Preclinical and Clinical Challenges

Joan Oliva1, Simone Pacini2, Josep M Canals3

  • 1Department of Clinical Research, Emmaus Life Sciences, Torrance, CA, United States.

Frontiers in Cell and Developmental Biology
|August 4, 2022
PubMed
Abstract

No abstract available in PubMed .

Keywords:
GMPMSCcell/gene therapiesregulationstranslational medicine

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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