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Lacosamide poisoning improved by hemodialysis
Hiroki Takahashi1, Takashi Muroya1, Yasutaka Okamoto1
1Department of Emergency and Critical Care Medicine Kansai Medical University Hirakata Japan.
Acute Medicine & Surgery
|August 4, 2022
Summary
Lacosamide (LCM) poisoning in a young woman was successfully treated with hemodialysis. This case demonstrates hemodialysis as an effective intervention for severe LCM overdose, leading to rapid recovery.
Area of Science:
- Pharmacology
- Toxicology
- Nephrology
Background:
- Lacosamide (LCM) is a third-generation antiepileptic drug known for its efficacy and safety profile.
- Despite its favorable side-effect profile, overdose cases require careful management.
Observation:
- A young woman presented with decreased consciousness after ingesting a large quantity of Lacosamide (328 tablets) and perampanel hydrate.
- Initial management included mechanical ventilation and activated charcoal.
- Clonic convulsions necessitated the initiation of hemodialysis.
Findings:
- Hemodialysis was initiated for severe Lacosamide poisoning.
- Following 4 hours of hemodialysis, seizure activity ceased.
- Blood Lacosamide levels significantly decreased post-hemodialysis (from 91.7 μg/mL to 18.3 μg/mL).
Implications:
- Hemodialysis is an effective treatment modality for severe Lacosamide poisoning.
- Prompt intervention with hemodialysis can lead to favorable patient outcomes in cases of significant antiepileptic drug overdose.
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