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Chronic Kidney Disease III: Interprofessional Care01:28

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Updated: Sep 2, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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The Complement System in Metabolic-Associated Kidney Diseases.

Ziyu Xu1, Li Tao1, Hua Su1

  • 1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Immunology
|August 4, 2022
PubMed
Summary
This summary is machine-generated.

Metabolic syndrome (MS) increases kidney disease risk. This review details how the complement system drives kidney damage in MS, offering new therapeutic targets.

Keywords:
complement systeminnate immunitykidney diseasesmetabolic syndromemetaflammation

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Area of Science:

  • Immunology
  • Nephrology
  • Metabolic Disorders

Background:

  • Metabolic syndrome (MS) affects 25% of the population, causing obesity, hypertension, and metabolic dysregulation.
  • Chronic inflammation, or 'metaflammation,' linked to MS, impacts organ function, particularly the kidneys.
  • The complement system, crucial for innate immunity, is increasingly implicated in metabolic kidney diseases.

Purpose of the Study:

  • To review complement system activation pathways in metabolic disturbances.
  • To elucidate mechanisms of complement-mediated kidney damage in MS.
  • To identify potential biomarkers and therapeutic strategies for metabolic kidney diseases.

Main Methods:

  • Literature review of studies on complement activation in metabolic syndrome.
  • Analysis of mechanisms linking complement to immune responses and kidney injury.
  • Synthesis of current knowledge on complement's role in metabolic kidney disease progression.

Main Results:

  • The complement system is activated through various pathways during metabolic disturbances.
  • Complement mediates immune cell infiltration, renal cell damage, and functional decline.
  • Specific complement components and activation pathways are associated with MS-related kidney pathology.

Conclusions:

  • The complement system is a key player in the pathogenesis of metabolic kidney diseases.
  • Targeting complement activation presents a promising therapeutic avenue for MS-induced kidney damage.
  • Further research into complement biomarkers could improve diagnosis and treatment of these conditions.