Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K
Knee Joint01:23

Knee Joint

2.1K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
2.1K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.2K
Bone Disorders01:29

Bone Disorders

3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
Bone Remodeling01:40

Bone Remodeling

38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

1.5K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sea Urchin Harvester's Hands: A Rheumatologic Mimicker.

International journal of rheumatic diseases·2026
Same author

Unravelling polyphenol skin permeation: A comparative study using full-thickness 3D in vitro and ex vivo human skin models.

International journal of cosmetic science·2026
Same author

Real-world safety data of first-line drugs for rheumatoid arthritis: insights from the Portuguese Reuma.pt database.

ARP rheumatology·2026
Same author

Growing Up with HIV: (Non)adaptive Processes in Perinatally-Infected Adolescents and Young Adults.

AIDS and behavior·2025
Same author

Design of Polymeric Delivery Systems for <i>Lycium barbarum</i> Phytochemicals: A Spray Drying Approach for Nutraceuticals.

Foods (Basel, Switzerland)·2025
Same author

Vanishing hips: unveiling Gorham-Stout syndrome.

ARP rheumatology·2025

Related Experiment Video

Updated: Sep 2, 2025

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.3K

Osteoarthritis' shifting paradigm - are we evolving?

Hugo Parente1, José Tavares-Costa1, Filipa Teixeira1

  • 1Reumatologia, Hospital Conde Bertiandos.

ARP Rheumatology
|August 4, 2022
PubMed
Summary

Osteoarthritis, the most common arthritis, is increasingly understood at the molecular level. This deeper comprehension is key to recognizing its diversity and improving patient treatment.

Area of Science:

  • Rheumatology
  • Molecular Biology
  • Epidemiology

Background:

  • Osteoarthritis (OA) is the predominant form of arthritis.
  • Traditionally viewed as mechanical, OA is now recognized as a complex molecular disease.
  • Understanding OA's molecular underpinnings is crucial for comprehending its varied presentations.

Purpose of the Study:

  • To highlight the evolving understanding of osteoarthritis from a mechanical to a molecular perspective.
  • To emphasize the importance of updated scientific knowledge in managing OA.
  • To advocate for a paradigm shift in OA treatment strategies.

Main Methods:

  • Review of current scientific literature on osteoarthritis.
  • Analysis of molecular mechanisms involved in OA pathogenesis.

More Related Videos

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

1.2K
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

6.1K

Related Experiment Videos

Last Updated: Sep 2, 2025

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.3K
A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

1.2K
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

6.1K
  • Synthesis of epidemiological data on OA prevalence.

    • Main Results:

    • Osteoarthritis exhibits significant molecular heterogeneity.
    • Molecular insights reveal OA's syndrome-like characteristics.
    • Current understanding moves beyond purely mechanical explanations.

    Conclusions:

    • A molecular-level understanding is essential for fully grasping osteoarthritis's complexity.
    • Disseminating updated scientific knowledge can accelerate better OA management.
    • Reframing OA as a multifaceted disease is vital for effective treatment of this widespread condition.