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Updated: Sep 2, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
[Renal infarction in an adolescent carrier of the sickle cell trait]
Abstract:
We report the case of a 15-year-old teenager, carrier of the sickle cell trait (haemoglobin AS), who presented a renal infarction. Besides, the patient also presented a renal ectopia. It is tempting to link these two particularities and the ischemic attack. The kidney is a target of this hemoglobinopathy, in its homozygous and possibly even heterozygous form. However, the analysis of the literature does not retain renal vascular accidents as a complication of sickle cell trait. Kidney position abnormalities also do not appear to be a contributing factor. It is, however, necessary to be attentive in adult heterozygous subjects to a faster than normal decline in glomerular filtration. The search for other risk factors (hypertension, diabetes, dyslipaemia) is desirable. The implementation of specific monitoring requires additional work.
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