Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

2.4K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
2.4K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

1.5K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.5K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

3.8K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
3.8K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

4.9K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
4.9K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

2.3K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
2.3K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

4.1K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Matched sampling reveals uncoupled phenotypic plasticity during metastasis formation in uveal melanoma.

iScience·2026
Same author

Hodgkin lymphoma: EHA Clinical Practice Guidelines for diagnosis, treatment, and follow-up.

HemaSphere·2026
Same author

Carbon dioxide is a triple vasodilator.

Cardiovascular research·2026
Same author

Nodular lymphocyte-predominant Hodgkin lymphoma controversy and insights: a global NLPHL one working group summit report.

Leukemia·2026
Same author

Corrigendum to ''3D approach visualizing cellular networks in human lymph nodes'' [Acta Histochem. 120 (8) (2018) 720-727].

Acta histochemica·2026
Same author

An agentic framework for autonomous scientific discovery in cancer pathology.

Nature medicine·2026
Same journal

Pathodashboard: an epidemiological atlas for tumour diagnostics.

Pathologie (Heidelberg, Germany)·2026
Same journal

Pathologie (Heidelberg, Germany)·2026
Same journal

Pathologie (Heidelberg, Germany)·2026
Same journal

[Genetic diagnostics].

Pathologie (Heidelberg, Germany)·2026
Same journal

[Guideline development for MRD diagnostics in AML as a blueprint for solid tumors].

Pathologie (Heidelberg, Germany)·2026
Same journal

[Therapy of melanoma : Current standards and future perspectives].

Pathologie (Heidelberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: Sep 2, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K

[Reactive lymphadenopathies].

Sylvia Hartmann1, Martin-Leo Hansmann2,3

  • 1Dr. Senckenbergisches Institut für Pathologie, Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland. s.hartmann@em.uni-frankfurt.de.

Pathologie (Heidelberg, Germany)
|August 4, 2022
PubMed
Summary
This summary is machine-generated.

Lymph nodes defend the body by filtering lymph fluid and fighting pathogens. This study details lymph node reactions and introduces 3D microscopy for enhanced diagnosis of immune responses and malignancies.

Keywords:
Castleman’s diseaseGerminal centreHistiocytic necrotizing lymphadenitisImmunoglobulin G4Three-dimensional imaging

More Related Videos

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
08:39

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

8.7K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.5K

Related Experiment Videos

Last Updated: Sep 2, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K
Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
08:39

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

8.7K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.5K

Area of Science:

  • Immunology and Haematopathology
  • Microscopy and Diagnostic Techniques

Background:

  • Lymph nodes are crucial for immune defense, filtering lymph and identifying threats like bacteria, viruses, and tumor cells.
  • Histological examination of lymph nodes reveals immune system strategies but often requires further investigation for precise diagnosis.
  • Distinguishing between reactive lymph node changes and malignant processes is a key challenge in haematopathology.

Purpose of the Study:

  • To detail various lymph node reactions for a better understanding of specific immune responses.
  • To improve the precision of diagnoses and reliably differentiate between reactive and malignant conditions.
  • To explore the application of three-dimensional (3D) microscopy in analyzing lymphoid tissue structure and function.

Main Methods:

  • Detailed description of diverse lymph node reactions based on histological examination.
  • Integration of results from conventional microscopy with novel three-dimensional (3D) microscopy techniques.
  • Analysis of fixed lymphoid tissue using 3D visualization to examine cellular morphology and interactions.

Main Results:

  • 3D microscopy provides enhanced visualization of morphological details within lymph nodes.
  • This approach offers new interpretations of cell-cell interactions and the functional roles of lymphoid compartments (e.g., germinal centers, T-zones).
  • Detailed understanding of lymph node reactions aids in accurate diagnosis and differentiation from malignancies.

Conclusions:

  • Detailed analysis of lymph node reactions, enhanced by 3D microscopy, improves diagnostic accuracy.
  • 3D visualization offers novel insights into immune cell interactions and lymphoid tissue organization.
  • This integrated approach is valuable for haematopathology, particularly in distinguishing benign from malignant lymph node conditions.