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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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[EBV-associated lymphoproliferative disorders]

Mathis Overkamp1,2, Leticia Quintanilla-Martinez1,2, Falko Fend3,4

  • 1Institut für Pathologie und Neuropathologie und Referenzzentrum für Hämatopathologie, Universitätsklinikum Tübingen, Liebermeisterstraße 8, 72076, Tübingen, Deutschland.

Pathologie (Heidelberg, Germany)
|August 4, 2022
PubMed

Epstein-Barr-virus-associated lymphoproliferations (EBV-LPD) constitute a wide spectrum from benign, self-limiting lymphoproliferations to malignant lymphoma. Because of the clinical and morphological heterogeneity of EBV-LPD and the high prevalence of EBV infections, knowledge of the diagnostic criteria is of great importance for the practice of diagnostic pathology. In this review, clinical and pathological characteristics of the non-malignant EBV-related LPD in patients with and without immunosuppression are presented and their current classification is discussed.EBV-LPD can be of B‑cell or T/NK-cell origin. Identification of EBV latency type and information about possible (iatrogenic) immunodeficiency of the patient are critical for diagnostic evaluation and separation from malignant lymphoma. The clinical context and the detection of EBV in T‑ and NK-cells are both essential for the diagnosis of EBV+ T/NK-cell LPD, which are rare in European countries.

Keywords:
EBV latency typeEpstein-Barr-virus infectionsImmunologic deficiencyInfectious mononucleosisLymphoma

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