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Difunisal in general practice.

E C Huskisson, T N Williams, L D Shaw

    Current Medical Research and Opinion
    |January 1, 1978
    PubMed
    Summary
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    Diflunisal demonstrated superior pain relief compared to aspirin for acute painful conditions. Diflunisal also showed better tolerance, with fewer gastric side effects than aspirin.

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Pain Management

    Background:

    • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for acute pain.
    • Comparing the efficacy and safety of different NSAIDs is crucial for clinical practice.

    Purpose of the Study:

    • To compare the efficacy and tolerance of diflunisal versus aspirin in patients with acute painful conditions.
    • To evaluate subjective pain relief and overall treatment response.

    Main Methods:

    • A large-scale, double-blind, comparative study in general practice.
    • 1902 patients with acute painful conditions (e.g., sprains, osteoarthritis) were enrolled.
    • Patients received either diflunisal (250 mg or 500 mg twice daily) or aspirin (600 mg 4-times daily) for 5 days.

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    Main Results:

    • Diflunisal showed significantly better pain relief than aspirin, based on patient daily records and overall assessments.
    • Gastric side effects were more frequent and severe with aspirin.
    • Treatment withdrawal due to side effects was more common with aspirin.

    Conclusions:

    • Diflunisal is a more effective and better-tolerated option than aspirin for managing acute painful conditions.
    • Diflunisal offers a favorable risk-benefit profile for pain management in primary care settings.