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Related Concept Videos

Colloidal precipitates01:09

Colloidal precipitates

732
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
732

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Related Experiment Video

Updated: Sep 2, 2025

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
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Colloidal Jamming by Interfacial Self-Assembled Polymers: A Robust Route for Ultrahigh Efficient Encapsulation.

Qingqing Huo1,2, Yue Gao1,2, Wenbo Wu1,2

  • 1State Key Laboratory of Natural Medicines, Department of Pharmaceutical Science, China Pharmaceutical University, Nanjing, 210009, China.

Angewandte Chemie (International Ed. in English)
|August 4, 2022
PubMed
Summary

Researchers developed a robust method using amphiphilic polymers to prevent cargo colloid phase transfer, achieving high encapsulation efficiency for proteins and peptides. This technique offers a promising solution for drug delivery applications.

Keywords:
ColloidsEncapsulationInterface JammingInterfacial Self-AssemblyPhase-Transfer

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Area of Science:

  • Materials Science
  • Colloid Science
  • Biotechnology

Background:

  • Controlling cargo phase-transfer is crucial for various scientific and technological applications.
  • Existing methods for preventing phase transfer can be complex or inefficient.

Purpose of the Study:

  • To develop a simple, versatile, and robust method for blocking cargo colloid phase-transfer.
  • To achieve ultrahigh encapsulation efficiency for proteins and peptides.

Main Methods:

  • Utilizing interfacial self-assembled amphiphilic polymer molecules at oil-water interfaces.
  • Modifying polymer concentration to induce a phase transition from flat to upright molecular orientation.
  • Forming a thick, three-dimensional polymer layer to prevent cargo migration.

Main Results:

  • Achieved ultrahigh encapsulation efficiency, up to 97.1%, for proteins and peptides.
  • Demonstrated robust prevention of phase-transfer even under significant external forces.
  • Successfully maintained normoglycemic state for 10 days in type 1 diabetic rats using insulin-loaded microcomposites.
  • Showcased a significantly reduced polymer mass requirement compared to non-amphiphilic alternatives.

Conclusions:

  • The developed method provides an effective strategy for blocking cargo phase-transfer.
  • Amphiphilic polymer interfacial layers offer robust protection and high encapsulation efficiency.
  • This approach holds significant potential for advanced drug delivery systems, particularly for sensitive biomolecules.