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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Related Experiment Video

Updated: Sep 2, 2025

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

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How I use platelet transfusions.

Simon J Stanworth1,2,3, Akshay Shah4,5

  • 1Department of Haematology, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom.

Blood
|August 4, 2022
PubMed
Summary
This summary is machine-generated.

Platelet transfusions may pose risks, with limited evidence of bleeding prevention. A restrictive, risk-adapted approach is recommended over policies solely based on platelet count.

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Related Experiment Videos

Last Updated: Sep 2, 2025

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Area of Science:

  • Hematology
  • Transfusion Medicine

Background:

  • Platelet transfusions are standard for bleeding prevention/treatment in acquired thrombocytopenia.
  • Recent data reveal uncertainties in the risk-benefit balance of platelet transfusions.

Approach:

  • This review examines current evidence on platelet transfusion efficacy and safety.
  • Analysis includes data from randomized trials and hemovigilance systems.

Key Points:

  • Platelets are frequently implicated in transfusion reactions.
  • Variable post-transfusion platelet increments and limited clinical outcome efficacy are observed.
  • Bleeding events occur despite prophylactic transfusion strategies.

Conclusions:

  • Platelet transfusion risks may stem from roles beyond hemostasis, such as mediating inflammation.
  • A restrictive platelet transfusion policy is supported by research.
  • Further research is needed on donation characteristics and optimal transfusion thresholds.