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Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Heart Failure I: Introduction01:27

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Heart Failure II: Pathophysiology01:29

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Pathophysiology of Heart Failure01:17

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Factors Affecting Renal Clearance: Renal Impairment01:17

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Global warming, renal function and heart failure over 20 years.

Alberto Aimo1, Josep Lupon2, Giosafat Spitaleri2

  • 1Scuola Superiore Sant'Anna, Pisa, Italy; Fondazione Toscana Gabriele Monasterio, Pisa, Italy.

International Journal of Cardiology
|August 4, 2022
PubMed
Summary

Increasing summer temperatures negatively impact kidney function in heart failure (HF) outpatients, showing higher creatinine and lower estimated glomerular filtration rate (eGFR). This highlights global warming

Keywords:
Climate changeCreatinineRenal functionSummerTemperatures

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Area of Science:

  • Environmental Health
  • Cardiology
  • Nephrology

Background:

  • The effects of rising ambient temperatures on kidney function in heart failure (HF) outpatients have not been previously investigated.
  • Understanding this relationship is crucial given the increasing prevalence of both HF and climate change.

Purpose of the Study:

  • To analyze the impact of increasing temperatures on renal function markers in heart failure outpatients.
  • To investigate the association between summer temperature variations and changes in creatinine and estimated glomerular filtration rate (eGFR).

Main Methods:

  • Retrieved creatinine and eGFR data from 2167 HF outpatients (2002-2021).
  • Collected corresponding monthly temperature data for summer and non-summer periods.
  • Analyzed associations between temperature fluctuations and renal function parameters, adjusting for covariates.

Main Results:

  • Patients exhibited significantly higher creatinine (0.04 mg/dL) and lower eGFR (-2.0 mL/min/1.73 m²) during summer months compared to the rest of the year.
  • A significant correlation was found between the rise in summer temperatures and elevations in creatinine and declines in eGFR over the 20-year study period.
  • These associations remained significant after adjusting for patient age, sex, baseline renal function, and HF therapies.

Conclusions:

  • Elevated summer temperatures are independently associated with a decline in renal function among heart failure outpatients.
  • The observed trend suggests a potential impact of global warming on human health, specifically on cardiovascular and renal systems.
  • Further research is warranted to explore the mechanisms and long-term implications of heat exposure on kidney health in vulnerable populations.