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Updated: Sep 2, 2025

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
Published on: February 6, 2012
Updates in 2022 on the staging of testicular germ cell tumors
Sofia Canete Portillo1, Soroush Rais-Bahrami2, Cristina Magi-Galluzzi3
1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Abstract:
Testicular cancer is the most common solid neoplasm of adult men between the ages of 20 and 40 years. Germ cell tumors account for 95% of all testicular tumors. The assessment of staging is essential to guide further management of patients with testicular cancer and to prognosticate cancer-related outcomes. Postradical orchiectomy treatment options, including adjuvant therapy and active surveillance, vary based on the anatomical extent of disease, serum tumor markers, pathologic diagnosis, and imaging. This review provides an update on the germ cell tumor staging system adopted by the 8th edition of the American Joint Commission on Cancer (AJCC) Staging Manual, treatment implications, risk factors, and predictors of outcomes.
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