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Thrombocytopenia and Bloodstream Infection: Incidence and Implication on Length of Stay in the Pediatric Intensive

Reut Kassif Lerner1,2, Dana Levinkopf3, Inna Zaslavsky Paltiel4

  • 1Department of Pediatric Intensive Care, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer, Israel.

Journal of Pediatric Intensive Care
|August 5, 2022
PubMed

Insights

Thrombocytopenia is common in critically ill children with bloodstream infections (BSI). This low platelet count is a risk marker for longer length of stay (LOS) in the pediatric intensive care unit (PICU).

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Infectious diseases

Background:

  • Bloodstream infection (BSI) is a significant concern in pediatric intensive care units (PICUs).
  • The prognostic implications of thrombocytopenia (low platelet count) in critically ill children with BSI are not well understood.
  • Identifying reliable prognostic markers is crucial for managing pediatric intensive care patients.

Purpose of the Study:

  • To determine the incidence of thrombocytopenia in critically ill pediatric patients with BSI.
  • To assess the relationship between thrombocytopenia and prognosis, specifically length of stay (LOS), in this patient population.
  • To evaluate thrombocytopenia as a potential risk marker for PICU LOS.

Main Methods:

  • Retrospective analysis of data from 2,349 pediatric patients admitted to a university hospital medical PICU over a 3-year period.
  • Identification of patients with BSI and assessment of their platelet counts.
  • Statistical analysis to compare outcomes, including LOS, between thrombocytopenic and non-thrombocytopenic patients.

Main Results:

  • The overall incidence of BSI was 3.9% (93/2,349 patients).
  • Thrombocytopenia occurred in 54.8% (51/93) of patients with BSI.
  • Thrombocytopenic patients with BSI had a significantly longer PICU length of stay compared to non-thrombocytopenic patients (p=0.007).

Conclusions:

  • Thrombocytopenia is a frequent complication in critically ill pediatric patients with bloodstream infections.
  • Low platelet count serves as a readily available and simple risk marker for predicting extended length of stay in the PICU.
  • Further research may explore interventions to manage thrombocytopenia and improve outcomes in these patients.

Keywords:
bloodstream infectioncritical carepediatric intensive care unitplateletssepsisthrombocytopenia

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