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Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease

Huzefa Rupawala1, Keshvi Shah1, Caitlin Davies2

  • 1Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, 5 Cutcombe Road, London SE5 9RX, UK.

Brain Communications
|August 5, 2022
PubMed
Summary

Cysteine string protein alpha (CSPα) is an early, sensitive marker for synapse loss in Alzheimer's disease (AD). Extracellular CSPα accumulations near beta-amyloid plaques indicate early synaptic dysfunction, even in other neurodegenerative diseases with plaques.

Keywords:
Alzheimer’s diseaseamyloid plaquecysteine string protein alphadystrophypre-synapse

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