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Updated: Sep 2, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
"Acute Kidney Injury predictive models: advanced yet far from application in resource-constrained settings."
Busisiwe Mrara1, Fathima Paruk2, Olanrewaju Oladimeji3
1Anaesthesiology and Critical Care, Walter Sisulu University, Mthatha, Eastern Cape, 5099, South Africa.
Abstract:
Acute kidney injury (AKI) remains a significant cause of morbidity and mortality in hospitalized patients, particularly critically ill patients. It poses a public health challenge in resource-constrained settings due to high administrative costs. AKI is commonly misdiagnosed due to its painless onset and late disruption of serum creatinine, which is the gold standard biomarker for AKI diagnosis. There is increasing research into the use of early biomarkers and the development of predictive models for early AKI diagnosis using clinical, laboratory, and imaging data. This field note provides insight into the challenges of using available AKI prediction models in resource-constrained environments, as well as perspectives that practitioners in these settings may find useful.
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