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Updated: Sep 2, 2025

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HS-1793 inhibits cell proliferation in lung cancer by interfering with the interaction between p53 and MDM2

Chungun Lim1,2, Peter C W Lee1,2,3, Sungbo Shim4

  • 1Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.

Oncology Letters
|August 5, 2022
PubMed

Insights

HS-1793, a resveratrol analog, inhibits lung cancer cell proliferation by stabilizing the tumor suppressor protein p53. This compound disrupts the p53-MDM2 interaction, a key mechanism in cancer progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The tumor suppressor protein p53 is crucial in regulating cellular functions and is implicated in various cancers.
  • HS-1793, a resveratrol analog, shows anti-cancer properties in multiple cancer types but its role in lung cancer is unexplored.

Purpose of the Study:

  • To investigate the anti-cancer effects of HS-1793 on lung cancer.
  • To determine the association between HS-1793 and the p53 pathway in lung cancer.

Main Methods:

  • Cell proliferation assays were performed on lung cancer cells treated with HS-1793.
  • Western blotting was used to assess the expression levels of p53, p21, and MDM2.
  • Analysis of the interaction between p53 and MDM2 was conducted.

Main Results:

  • HS-1793 significantly reduced lung cancer cell proliferation.
  • HS-1793 increased the stability of p53 protein.
  • Elevated expression of p53 target genes, p21 and MDM2, was observed.
  • HS-1793 inhibited the binding of MDM2 to p53, preventing p53 degradation.

Conclusions:

  • HS-1793 exhibits anti-cancer effects in lung cancer by enhancing p53 stability.
  • The mechanism involves disrupting the p53-MDM2 interaction, suggesting HS-1793 as a potential therapeutic agent for lung cancer.
Keywords:
HS-1793MDM2anti-cancerlung cancerp53

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