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Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections.

Iris Medits1, David N Springer1, Marianne Graninger1

  • 1Center for Virology, Medical University of Vienna, Vienna, Austria.

Frontiers in Immunology
|August 5, 2022
PubMed
Summary
This summary is machine-generated.

Primary Omicron BA.1 or BA.2 infections induced variant-specific neutralizing antibodies. However, vaccination-breakthrough infections with Omicron variants generated broad cross-neutralizing antibody levels against SARS-CoV-2 variants.

Keywords:
Omicron sub-lineagesSARS-CoV-2SARS-CoV-2 neutralizationSARS-CoV-2 variant of concernimmune escape

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Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) exhibits significant antigenic divergence.
  • Its heavily mutated spike protein facilitates immune escape, necessitating studies on neutralization escape.

Purpose of the Study:

  • To investigate serum-neutralizing activities following Omicron BA.1 or BA.2 sub-lineage infections in naïve and vaccinated individuals.
  • To compare neutralization against Omicron BA.1, Omicron BA.2, wildtype (WT), and Delta strains.

Main Methods:

  • Live virus neutralization tests were performed using serum samples from individuals with primary Omicron infections (BA.1 or BA.2), WT infections, and three-dose mRNA vaccinations.
  • Control groups included vaccinated individuals with and without prior infection.

Main Results:

  • Primary BA.1 infections led to reduced neutralization against WT, Delta, and BA.2. BA.2 infections showed minimal cross-neutralization.
  • Three-dose mRNA vaccination provided detectable but reduced neutralization against Omicron variants.
  • Vaccination-breakthrough infections with BA.1 or BA.2 elicited comparable cross-neutralizing antibody levels against all tested SARS-CoV-2 variants.

Conclusions:

  • Omicron variants can enhance cross-neutralizing antibody levels in pre-immune individuals.
  • Primary Omicron infections induce predominantly variant-specific antibodies, highlighting distinct immune responses between BA.1 and BA.2.
  • Findings are crucial for understanding antibody responses to diverse SARS-CoV-2 exposures and for future vaccine development strategies.