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Updated: Sep 2, 2025

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Published on: July 22, 2020
Hiding in Plain Sight: A Novel Microbial Driver for Colorectal Cancer?
Tejeshwar Jain1, Vikas Dudeja1
1Division of Surgical Oncology at Department of Surgery, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama.
Summary:
In this issue of Cancer Discovery, Drewes and colleagues demonstrate a surprising role for the common gut pathogen Clostridioides difficile in driving colorectal cancer in preclinical models through the bacterial toxin-dependent reprogramming of the epithelial and immune compartments. See related article by Drewes et al., p. 1873 (3).
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